Detailed publication list: https://pubmed.ncbi.nlm.nih.gov/?term=georgakis+mk&sort=date
Omarov M, Zhang L, Doroodgar Jorshery S, Malik R, Das B, Belomo TR, Mansmann U, Menten MJ, Natarajan P, Dichgans M, Raghu VK, Anderson CD, Georgakis MK. Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis. MedRxiv [Preprint]. 2024.10.17.24315675.
Link: https://www.medrxiv.org/content/10.1101/2024.10.17.24315675v1
Prapiadou S, Živković L, Thorand B, George MJ, van der Laan SW, Malik R, Herder C, Koenig W, Ueland T, Kleveland O, Aukrust P, Gullestad L, Bernhagen J, Pasterkamp G, Peters A, Hingorani AD, Rosand J, Dichgans M, Anderson CD, Georgakis MK. Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis. Circulation. 2024 Feb 27;149(9):669-683.
Fang R, Duering M, Bode FJ, …, Georgakis MK*, Dichgans M*. Risk factors and clinical significance of post-stroke incident ischemic lesions (*equally contributed). Alzheimers Dement. 2024 Oct 17. Online ahead of print.
Link: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14274
Konieczny M, Omarov M, Malik R, Richardson TG, Baumeister SE, Bernhagen J, Dichgans M, Georgakis MK. The Genomic Architecture of Circulating Cytokine Levels Points to Drug Targets for Immune-Related Diseases. MedRxiv [Preprint]. 2024.04.19.24306036.
Link: https://www.medrxiv.org/content/10.1101/2024.04.19.24306036v1
Myserlis EP, Ray A, Anderson CD, Georgakis MK. Genetically proxied IL-6 signaling and risk of Alzheimer’s disease and lobar intracerebral hemorrhage: A drug target Mendelian randomization study. Alzheimers Dement (N Y). 2024 Aug 27;10(3):e70000.
Link: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70000
Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, …, Liesz A. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature. 2024 Sep;633(8029):433-441.
Link: https://www.nature.com/articles/s41586-024-07803-4
Risk factors for cognitive impairment and dementia after stroke: a systematic review and meta-analysisFiller J, Georgakis MK, Dichgans M. Lancet Healthy Longev. 2024 Jan;5(1):e31-e44.
Link: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00217-9/fulltext
Georgakis MK, Malik R, El Bounkari O, …, Dichgans M. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. MedRxiv [Preprint]. 2023.08.14.23294063.
Link: https://www.medrxiv.org/content/10.1101/2023.08.14.23294063v3
Myserlis EP, Anderson CD, Georgakis MK. Genetically Proxied CRP (C-Reactive Protein) Levels and Lobar Intracerebral Hemorrhage Risk. Stroke. 2023 Apr;54(4):e130-e132.
Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041889
Myserlis EP*, Georgakis MK*, Demel SL, Sekar P, Chung J, Malik R, Hyacinth HI, Comeau ME, Falcone GJ, Langefeld CD, Rosand J, Woo D, Anderson CD. A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage (*equally contributed). Stroke. 2023 Apr;54(4):973-982.
Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041701
Mayerhofer E, Parodi L, Prapiadou S, Malik R, Rosand J, Georgakis MK*, Anderson CD*. Genetic Risk Score Improves Risk Stratification for Anticoagulation-Related Intracerebral Hemorrhage (*equally contributed). Stroke. 2023 Mar;54(3):791-799.
Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041764
Georgakis MK, Anderson CD. Polygenic Risk Scores in the Clinic: A Case for Stroke Survivors. Neurology. 2023 Apr 11;100(15):693-695.
Link: https://www.neurology.org/doi/10.1212/WNL.0000000000206899
Georgakis MK, Bernhagen J, Heitman L, Weber C, Dichgans M. Targeting the CCL2-CCR2 Axis for Atheroprotection: Triangulation of Evidence and Steps Towards Clinical Translation. Eur Heart J. 2022 May 14;43(19):1799-1808.
Link: https://academic.oup.com/eurheartj/article/43/19/1799/6543079
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, …, Debette S. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Sep 30;1-15.
Link: https://www.nature.com/articles/s41586-022-05165-3
Mayerhofer E, Malik R, Parodi L, Burgess S, Harloff A, Dichgans M, Rosand J, Anderson CD, Georgakis MK. Genetically predicted on-statin LDL response is associated with higher intracerebral haemorrhage risk. Brain. 2022 Aug 27;145(8):2677-2686.
Link: https://academic.oup.com/brain/article/145/8/2677/6590424
De Marchis GM, Dittrich TD, Malik R , Zietz AV , Kriemler LF, Ference BA , Dichgans M , Georgakis MK. Genetic proxies for PCSK9 inhibition associate with lipoprotein(a): Effects on coronary artery disease and ischemic stroke. Atherosclerosis. 2022 Sep 26;S0021-9150(22)01433-2.
Link: https://www.atherosclerosis-journal.com/article/S0021-9150(22)01433-2/fulltext
Georgakis MK, Malik R, Richardson TG, Howson JMM, Anderson CD, Burgess S, Hovingh GK, Dichgans M, Gill D. Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups. BMC Med. 2022 Aug 11;20(1):245.
Link: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02446-6
Georgakis MK, Parodi L, Frerich S, …, Anderson CD. Genetic architecture of stroke of undetermined source: overlap with known stroke etiologies and associations with modifiable risk factors. Ann Neurol. 2022 May;91(5):640-651.
Link: https://onlinelibrary.wiley.com/doi/10.1002/ana.26332
Georgakis MK, Rong F, Düring M, …, Dichgans M. Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study. Alzheimers Dement. 2022 Jul 25. Online ahead of print.
Link: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12744
Živković L, Asare Y, Bernhagen J, Dichgans M, Georgakis MK. Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies. Arterioscler Thromb Vasc Biol. 2022 May;42(5):e131-e144.
Papadopoulos A, Palaiopanos K, Björkbacka H, …, Georgakis MK. Circulating interleukin-6 levels and incident ischemic stroke: a systematic review and meta-analysis of prospective studies. Neurology. 2022 Mar 8;98(10):e1002-e1012.
Link: https://n.neurology.org/content/98/10/e1002.long
Georgakis MK, Malik R, Burgess S, Dichgans M. Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density-Lipoprotein Cholesterol Lowering on Cardiovascular Risk: A 2X2 Factorial Mendelian Randomization Analysis. J Am Hear Assoc. 2022 Jan 4;11(1):e023277.
Georgakis MK, van der Laan S., Asare Y., …, Dichgans M. Monocyte-chemoattractant protein-1 Levels in Human Atherosclerosis Associate with Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2021;41(6):2038-2048.
Link: https://www.ahajournals.org/doi/10.1161/ATVBAHA.121.316091
Georgakis MK, Gill D. Mendelian Randomization Studies in Stroke: Exploration of Risk Factors and Drug Targets With Human Genetic Data. Stroke. 2021. Aug;52(9):2992-3003.
Link: https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.032617
Georgakis MK, de Lemos JA, Ayers C, …, Dichgans M. Circulating monocyte chemoattractant protein-1 levels are associated with cardiovascular mortality: a meta-analysis of population-based studies. JAMA Cardiol. 2021;6(5):587-592.
Link: https://jamanetwork.com/journals/jamacardiology/fullarticle/2772316
Georgakis MK, Malik R, Li X, …, Dichgans M. Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association study. Circulation. 2021;143(11):1177-1180.
Link: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.052604
Malik R*, Georgakis MK*, Neitzel J, …, Dichgans M. Midlife vascular risk factors and risk of incident dementia: longitudinal cohort and Mendelian randomization analyses in the UK Biobank. (*equally contributed). Alzheimers Dement. 2021;17(9):1422-1431.
Link: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12320
Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Burgess S, Dichgans M, Gill D. Relationship between blood pressure and incident cardiovascular disease: linear and non-linear Mendelian randomization analyses. Hypertension. 2021;77(6):2004-2013.
Link: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16534
Georgakis MK, Harshfield E, Malik R, …, Dichgans M. Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study. Neurology. 2021;96(13):e1732-e1742.
Georgakis MK, Malik R, Gill D, …, Dichgans M. Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian Randomization study. Circ Genom Precis Med. 2020;13(3):e002872.
Link: https://www.ahajournals.org/doi/10.1161/CIRCGEN.119.002872
Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M. Genetically determined blood lipids and cerebral small vessel disease: role of HDL cholesterol. Brain. 2020;143(2):597-610.
Link: https://academic.oup.com/brain/article/143/2/597/5714182?login=false
Papadopoulos A, Palaiopanos K, Protogerou AP, Paraskeuas G, Tsivgoulis G, Georgakis MK. Left ventricular hypertrophy and cerebral small vessel disease: a systematic review and meta-analysis. J Stroke. 2020;22(2):206-224.
Link: https://www.j-stroke.org/journal/view.php?number=318
Georgakis MK, Gill D, Malik R, Protogerou AD, Webb WJS,…, Dichgans M. Genetically predicted blood pressure across the lifespan: differential effects of mean and pulse pressure on stroke risk. (*equally contributed). Hypertension. 2020 Sep;76(3):953-961.
Link: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15136
Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M. Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke: a Mendelian Randomization Study. Neurology. 2020 Jul 28;95(4):e353-e361.
Link: https://n.neurology.org/content/95/4/e353
Marini S*, Georgakis MK*, …, Andreson CD. Genetic overlap and causal inferences between impaired kidney function and cerebrovascular diseases. Neurology. 2020;94(24):e2581-e2591. (*equally contributed).
Link: https://n.neurology.org/content/94/24/e2581/tab-article-info
Georgakis MK, Malik R, Björkbacka H, …, Dichgans M. Circulating monocyte chemoattractant protein-1 and risk of stroke: a meta-analysis of population-based studies involving 17,180 individuals. Circ Res 2019;125(8):773-782.
Georgakis MK, Gill D, Rannikmäe K, …, Dichgans M. Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1. Circulation 2019;139(2):256-268.
Link: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.035905
Gill D*, Georgakis MK*, Koskeridis F, …, Dichgans M*, Tzoulaki I*. Use of Genetic variants related to antihypertensive targets to inform on efficacy and side effects. Circulation. 2019;140(4):270-279. (*equally contributed)
Link: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.118.038814
Georgakis MK, Duering M, Wardlaw JM, Dichgans M. WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis. Neurology. 2019;92(12):e1298-e1308.
Link: https://n.neurology.org/content/92/12/e1298
Georgakis MK, Beskou-Kontou T, Theodoridis I, Skalkidou A, Petridou ET. Surgical menopause in association with cognitive function and risk of dementia: A systematic review and meta-analysis. Psychoneuroendocrinology. 2019 Aug; 106:9-19.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0306453018311478?via%3Dihub
Zietemann V*, Georgakis MK*, Dondaine T, Müller C, Mendyk AM, Kopczak A, Hénon H, Bombois S, Wollenweber FA, Bordet R, Dichgans M. Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke. Neurology. 2018;91(20):e1838-e1850. (*equally contributed)
Link: https://n.neurology.org/content/91/20/e1838
Georgakis MK, Chatzopoulou D, Tsivgoulis G, Petridou ET. Albuminuria and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2018;66(3):509-517.
Link: https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.15240
Georgakis MK, Dimitriou NG, Karalexi MA, …, Petridou ET. Albuminuria in association with dementia and cognitive function: a systematic review and meta-analysis. J Am Ger Soc. 2017;65(6):1190-1198.
Link: https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.14750
Georgakis MK, Synetos A, Mihas C, Karalexi MA, Tousoulis D, Seshadri S, Petridou ET. Left ventricular hypertrophy in association with cognitive impairment: a systematic review and meta-analysis. Hypertens Res. 2017 Jul;40(7):696-709.
Georgakis MK, Kalogirou EI, Diamantaras AA, Daskalopoulou SS, Munro CA, Lyketsos CG, Skalkidou A, Petridou ET. Age at menopause and duration of reproductive period in association with dementia and cognitive function: A systematic review and meta-analysis. Psychoneuroendocrinology. 2016 Nov;73:224-243.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0306453016305182?via%3Dihub
Georgakis MK, Thomopoulos TP, Diamantaras AA, Kalogirou EI, Skalkidou A, Daskalopoulou SS, Petridou ET. Age at menopause and duration of reproductive period in association with depression in postmenopausal women: a systematic review and meta-analysis. JAMA Psychiatry. 2016;73(2):139-149.
Link: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2480951
