February 2024 – Integrating genetic information from >520,000 individuals with data from plasma proteomics, the team of Marios Georgakis identified a proteomic signature of IL-6 signaling activation and mediators of its effects on cardiovascular disease. Their analyses suggest, that the interferon-γ-inducible chemokine CXCL10 is a potentially causal mediator for atherosclerosis in different vascular beds (coronary, […]

April 2024 – Murad presented his work on deep learning analyses of carotid ultrasound images at the ISGC meeting in Munich.

May 2024 – New lab preprint on the genetic architecture of circulating cytokine levels. By analyzing genomic data for 40 cytokines from >70,000 individuals, we were able to detect 169 genomic signals, four of which pointed to key targets for the development of novel tailored immunotherapies against autoimmune disease. The GWAS data were made freely […]

October 2024 – New lab preprint on the the use of deep learning for assessing atherosclerotic plaques in carotid ultrasound. By assessing 180,000 ultrasound images from 20,000 individuals in the UK Biobank, we developed a model for accurate automatic plaque detection. The model predictions improved risk assessment for cardiovascular disease and provided novel insights into […]